Structural MRI and Diffusion Tensor Imaging (DTI) in Asperger Sydrome

The ARC and the Brain Mapping Unit are the Cambridge node of a multi-centre study of neuroanatomy and brain function in autism, called the EU AIMS (Autism Interventions Multicentre Study). The study is led by Institute of Psychiatry, Director Prof Declan Murphy). This project will scan 500 people with autism spectrum conditions and 300 age-matched controls to measure cortical thickness, major tracts (using DTI) and volumetric differences in defined brain regions (using structural MRI). The ARC was also part of the MRC-AIMS study (Autism Imaging Multicentre Study) of males with Asperger Syndrome, and initiated a related project examining brain structure and function in women with Asperger Syndrome.

Selected References

710: M Catani, F Dell’Acqua, S Budisavljevic, H Howells, M Thiebaut de Schotten, S Froudist-Walsh, L D’Anna, A Thompson, S Sandrone, E Bullmore, J Suckling, S Baron-Cohen, M Lombardo, S Wheelwright, B Chakrabarti, M-C Lai, A Ruigrok, A Leemans, C Ecker MRC AIMS Consortium, M Craig, D Murphy1 (2016)
Frontal networks in adults with autism spectrum disorder
Brain 139:616–630

678: D Floris, M-C Lai, T Auer, M Lombardo, C Ecker, B Chakrabarti, S Wheelwright, E Bullmore, D Murphy, S Baron-Cohen, J Suckling (2016)
Atypically Rightward Cerebral Asymmetry in Male Adults With Autism Stratifies Individuals With and Without Language Delay
Human Brain Mapping 37:230-253

685: J Balardin, W Comfort, E Daly, C Murphy, D Andrews, D Murphy, C Ecker, MRC AIMS Consortium, J Sato (2015)
Decreased centrality of cortical volume covariance networks in autism spectrum disorders
Journal of Psychiatric Research 69:142-149

653: D Lisiecka, R Holt, R Tait, M Ford, M-C Lai, L Chura, S Baron-Cohen, M Spencer, J Suckling (2015)
Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence
Translational Psychiatry 5:e529

649: J Balardin, J Sato, G Vieira, Yeu Feng, E Daly, C Murphy, MRC AIMS Consortium, D Murphy, C Ecker (2015)
Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay
Autism Research 8:556-566

629: M-C Lai, M Lombardo, C Ecker, B Chakrabarti, J Suckling, E Bullmore, F Happé, MRC AIMS Consortium, D Murphy, S Baron-Cohen (2015)
Neuroanatomy of Individual Differences in Language in Adult Males with Autism
Cerebral Cortex 25:3613-3628

630: S. C. L. Deoni, J. R. Zinkstok, E. Daly, C. Ecke, MRC AIMS Consortium, S. C. R. Williams, D. G. M. Murphy (2014)
White-matter relaxation time and myelin water fraction differences in young adults with autism
Psychological Medicine 45:795-805

574: JR Sato,MQ Hoexter, PP de Magalhães Oliveira Jr.,M Brammerd, MRC AIMS Consortium, D Murphy, C Ecker (2013)
Inter-regional cortical thickness correlations are associated with autistic symptoms: A machine-learning approach
Journal of Psychiatric Research 47:453-459

573: A Christakou, CM Murphy, K Chantiluke, AI Cubillo, AB Smith, V Giampietro, E Daly, C Ecker, D Robertson, MRC AIMS consortium, DG Murphy, K Rubia (2013)
Disorder-specific functional abnormalities during sustained attention in youth with Attention Deficit Hyperactivity Disorder (ADHD) and with Autism
Molecular Psychiatry 18:236-244

562: C Ecker, C Ginestet, Y Feng, P Johnston, M Lombardo, M-C Lai, J Suckling, L Palaniyappan, E Daly, C Murphy, S Williams, E Bullmore, S Baron-Cohen, M Brammer, D Murphy, for the MRC AIMS Consortium (2013)
Brain Surface Anatomy in Adults With Autism: The Relationship Between Surface Area, Cortical Thickness, and Autistic Symptoms
JAMA Psychiatry 70(1):59-70

561: C Ecker, L Ronan, Y Feng, E Daly, C Murphy, C Ginestet, M Brammer, P Fletcher, E T Bullmore, J Suckling, S Baron-Cohen, S Williams, E Lotha, MRC AIMS Consortium3, D Murphy (2013)
Intrinsic gray-matter connectivity of the brain in adults with autism spectrum disorder
PNAS 110(32):13222-13227

559: M-C Lai, M Lombardo, J Suckling, A Ruigrok, B Chakrabarti, C Ecker, S Deoni, M Craig, D Murphy, E Bullmore, MRC AIMS Consortium, S Baron-Cohen (2013)
Biological sex affects the neurobiology of autism
Brain 136:2799-2815

699: M Langen, A Leemans, P Johnston, C Ecker, E Daly, C Murphy, F dell’Acqua, S Durston, the AIMS Consortium, D Murphy (2012)
Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography
Cortex 48:183-193

531: M-C Lai, M V Lombardo, B Chakrabarti, C Ecker, S A Sadek, S J Wheelwright, D G M Murphy, John Suckling, E T Bullmore, MRC AIMS Consortium, S Baron-Cohen (2012)
Individual differences in brain structure underpin empathizing–systemizing cognitive styles in male adults
NeuroImage 61:1347–1354

530: C Ecker, J Suckling, S Deoni, M Lombardo, E Bullmore, S Baron-Cohen, M Catani, P Jezzard, A Barnes, A Bailey, S Williams, D Murphy, for the MRC AIMS Consortium (2012)
Brain Anatomy and Its Relationship to Behavior in Adults With Autism Spectrum Disorder: A Multicenter Magnetic Resonance Imaging Study
Archives of General Psychiatry 69(2):195-209