Candidate Gene Association Studies

This genetic association study is examining specific candidate genes chosen for their role in neural development or neural function, to see if single nucleotide polymorphisms (SNPs) in these candidate genes differ in their frequencey between cases and controls; or if these SNPs are associated with phenotypic measures that we have developed (such as the Autism Spectrum Quotient (AQ)). We are also conducting full genome association scans using chips with 50,000 SNPs. We aim to test if the same or different associations are found in Asperger Syndrome and classic autism.

 

Selected References

670: V Warrier, V Chee, P Smith, B Chakrabarti, S Baron-Cohen (2015)
A comprehensive meta-analysis of common genetic variants in autism spectrum conditions
Molecular Autism 6:49

652: A Di Napoli, V Warrier, S Baron-Cohen, B Chakrabarti (2015)
Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome
Molecular Autism 6:9

690: J Durdiakov√°, V Warrier, S Baron-Cohen, B Chakrabarti (2014)
Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome
Molecular Autism 5:25

631: Di Napoli, V Warrier, S Baron-Cohen, B Chakrabarti (2014)
Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome
Molecular Autism 5:48

600: J Durdiakov√°, V Warrier, S Banerjee-Basu, S Baron-Cohen, B Chakrabarti (2014)
STX1A and Asperger syndrome: a replication study
Molecular Autism 5:14

594: V Warrier, S Baron-Cohen, B Chakrabarti (2013)
Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism
Molecular Autism 4:48

317: B. Chakrabarti, L. Kent, J. Suckling, E. Bullmore and S. Baron-Cohen (2006)
Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
European Journal of Neuroscience 23:1944-1948

101: S. Baron-Cohen and J. Hammer (1997)
Parents of Children with Asperger Syndrome: What is the Cognitive Phenotype?
Journal of Cognitive Neuroscience 9(4):548-554


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