Structural and Functional MRI of Autism and Broader Phenotype

This project, also known as The Cambridge Family Study of Autism, investigates autism and its extended phenotype by scanning teenagers with Asperger Syndrome or High-Functioning Autism (HFA), unaffected siblings and typically developing controls, using structural and functional magnetic resonance imaging (MRI). This project was originally funded by an MRC Clinician Scientist Fellowship to Dr Michael Spencer and is now led by Prof John Suckling.

Selected References

689: T Simas, S Chattopadhyay, C Hagan, P Kundu, A Patel, R Holt, D Floris, J Graham, C Ooi, R Tait, M Spencer, S Baron-Cohen, B Sahakian, E Bullmore, I Goodyer, J Suckling (2015)
Semi-Metric Topology of the Human Connectome: Sensitivity and Specificity to Autism and Major Depressive Disorder
PLoS ONE 10(8):e0136388

677: R Moseley, R Ypma, R Holt, D Floris, L Chura, M Spencer, S Baron-Cohen, J Suckling, E Bullmore, M. Rubinov (2015)
Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents
NeuroImage: Clinical 9:140-152

653: D Lisiecka, R Holt, R Tait, M Ford, M-C Lai, L Chura, S Baron-Cohen, M Spencer, J Suckling (2015)
Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence
Translational Psychiatry 5:e529

617: R Holt, L Chura, M-C Lai, J Suckling, E von dem Hagen, A Calder, E Bullmore, S Baron-Cohen, M Spencer (2014)
‘Reading the Mind in the Eyes’: an fMRI study of adolescents with autism and their siblings
Psychological Medicine 44:3215-3227

607: F Segovia, R Holt, M Spencer, J Górriz, J Ramírez, C Puntonet, C Phillips, L Chura, S Baron-Cohen, J Suckling (2014)
Identifying endophenotypes of autism: a multivariate approach
Frontiers in Computational Neuroscience 8:60

702: M Spencer, L Chura, R Holt, J Suckling, A Calder, E Bullmore, S Baron-Cohen (2012)
Failure to deactivate the default mode network indicates a possible endophenotype of autism
Molecular Autism 3:15

540: M Spencer, R J Holt, L R Chura, A J Calder, J Suckling, E T Bullmore, S Baron-Cohen (2012)
Atypical activation during the Embedded Figures Task as a functional magnetic resonance imaging endophenotype of autism
Brain 135:3469-3480

517: M. Spencer, R. Holt, L. Chura, J. Suckling, A. Calder, E. Bullmore S. Baron-Cohen (2011)
A novel functional brain imaging endophenotype of autism: the neural response to facial expression of emotion
Translational Psychiatry 1:e19


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